研究業績

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2021

Ohmura Y, Iwami K, Chowdhury S, Sasamori H, Sugiura C, Bouchekioua Y, Nishitani N, Yamanaka A, Yoshioka M.

Disruption of model-based decision making by silencing of serotonin neurons in the dorsal raphe nucleus.
Current Biology, accepted.

Mizuta K, Nakai J, Hayashi Y, Sato M 

Multiple coordinated cellular dynamics mediate CA1 map plasticity.
Hippocampus, 31(3): 235-243, 2021

Tomaru U, Ito T, Ohmura Y, Higashikawa K, Miyajima S, Tomatsu R, Higashi T, Ishizu A, Kuge Y, Yoshioka M, Kasahara M.

Decreased proteasomal function induces neuronal loss and memory impairment.
The American Journal of Pathology, 2021, 191:144-156.

Bouchekioua Y, Blaindell AP, Kosaki Y, Tsutsui-Kimura I, Craddock P, Mimura M, Watanabe S.

Spatial inference without a cognitive map: the role of higher-order path integration
Biol Rev Camb Philos Soc, 96(1): 52-65, 2021

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2020

Aikawa K, Yoshida T, Ohmura Y, Lyttle, K, Yoshioka M, Morimoto Y.

Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress.
Brain Res, 2020, 1746: 146980.

Miura I, Sato M, Overton ETN, Kunori N, Nakai J, Kawamata T, Nakai N, Takumi T.

Encoding of social exploration by neural ensembles in the insular cortex
PLOS Biol, 2020, 18:e3000584

Miura I, Overton ETN, Kunori N, Nakai N, Kawamata T, Sato M, Takumi T.

Imaging the neural circuit basis of social behavior: insights from mouse and human studies
Neurol Med Chir (Tokyo), 2020, 60:429-438

Sato M, Mizuta K, Islam T, Kawano M, Sekine Y, Takekawa T, Gomez-Dominguez D, Schmidt A, Wolf F, Kim K, Yamakawa H, Ohkura M, Lee MG, Fukai T, Nakai J, Hayashi Y.

Distinct mechanisms of over-representation of landmarks and rewards in the hippocampus
Cell Rep, 2020, 32:107864

Chiba H, Kitta T, Ohmura Y, Higuchi M, Kon M, Nakamura M, Yoshioka M, Shinohara N.

Serotonin in the rat prefrontal cortex controls the micturition reflex via 5-HT2A and 5-HT7 receptors.
International Journal of Urology, 2020, 27:684-689.

Luchetti A, Bota A, Weitemier A, Mizuta K, Sato M, Islam T, McHugh TJ, Tashiro A, Hayashi Y.

Two functionally distinct serotonergic projections into hippocampus
J Neurosci, 2020, 40:4936-4944

Sugimoto H, Sato M, Nakai J, Kawakami K

Astrocytes in Atp1a2-deficient heterozygous mice exhibit hyperactivity after the induction of cortical spreading depression
FEBS Open Bio, 2020, 10:1031-1043

Sato M, Sano S, Watanabe H, Nakai J

An aspherical microlens assembly for deep brain fluorescence microendoscopy
Biochem Biophys Res Commun, 2020, 527:447-452

Nebuka M, Ohmura Y, Izawa S, Bouchekioua Y, Nishitani N, Yoshida T, Yoshioka M.

Behavioral Characteristics of 5-HT2C Receptor Knockout Mice: Locomotor activity, Anxiety-, and Fear Memory-related Behaviors.
Behavioural Brain Research, 2020, 379:112394.

Ohmura Y, Tsutsui-Kimura I, Sasamori H, Nebuka M, Nishitani N, Tanaka KF, Yamanaka A, Yoshioka M.

Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects.
Neuropharmacology, 2020, 167:107703.

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2019

Izawa S, Chowdhury S, Miyazaki T, Mukai Y, Ono D, Inoue R, Ohmura Y, Mizoguchi H, Kimura K, Yoshioka M, Terao A, Kilduff T, Yamanaka A.

REM sleep-active MCH neurons are involved in forgetting hippocampus-dependent memories.
Science. 2019, 365: 1308-1313.

Nishitani N, Sasamori H, Ohmura Y, Yoshida T, Yoshioka M.

Blonanserin Suppresses Impulsive Action in Rats.
J Pharmacol Sci., 2019, 141: 127-130.

Nishitani N, Ohmura Y, Nagayasu K, Shibui N, Kaneko S, Ohashi A, Yoshida T, Yamanaka A, Yoshioka M.

CRISPR/Cas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice.
Brain Research, 1719 (2019) 243–252.

Sasamori H, Ohmura Y, Yoshida T, Yoshioka M.

Noradrenaline reuptake inhibition increases control of impulsive action by activating D1-like receptors in the infralimbic cortex.
Eur J Pharmacol, 2019, 844: 17-25.

Ohmura Y, Tsutsui-Kimura I, Sasamori H, Nebuka M, Nishitani N, Tanaka KF, Yamanaka A, Yoshioka M.

Different roles of distinct serotonergic pathways in anxiety-like behavior, antidepressant-like, and anti-impulsive effects.
Neuropharmacology, 2020, 167:107703.

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2018

Sasamori H, Ohmura Y, Kubo T, Yoshida T, Yoshioka M.

Assessment of impulsivity in adolescent mice: a new training procedure for a 3-choice serial reaction time task
Behavioural Brain Research, 2018 May 2;343:61-70. Epub 2018 Jan 31.

Kumamoto H, Yamaguchi T, Konno K, Izumi T, Yoshida T, Ohmura Y, Watanabe M, Yoshioka M.

Repeated fluvoxamine treatment recovers early postnatal stress-induced hypersociability-like behavior in adult rats.
J Pharmacol Sci., 2018 Jan;136(1):1-8. Epub 2017 Dec 9.

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2017

Tsutsui-Kimura I, Ohmura Y, Yoshida T, Yoshioka M.

Milnacipran affects mouse impulsive, aggressive, and depressive-like behaviors in a distinct dose-dependent manner.
J Pharmacol Sci., 2017 Jul;134(3):181-189. Epub 2017 Jun 27.

Minami S, Satoyoshi H, Ide S, Inoue T, Yoshioka M, Minami M.

Suppression of reward-induced dopamine release in the nucleus accumbens in animal models of depression: differential responses to drug treatment.
Neurosci Lett. 2017 Apr 18. pii: S0304-3940(17)30329-4.

Hasegawa E, Maejima T, Yoshida T, Masseck A O, Herlitze S, Yoshioka M, Sakurai T, and Mieda M

Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity
Proc Natl Acad Sci U S A. 2017 Epub 2017 April 10.

Ohmura Y, Sasamori H, Tsutsui-Kimura I, Izumi T, Yoshida T, Yoshioka M.

Varenicline provokes impulsive action by stimulating α4β2 nicotinic acetylcholine receptors in the infralimbic cortex in a nicotine exposure status-dependent manner.
Pharmacol Biochem Behav. 2017 Mar;154:1-10. Epub 2017 Jan 10.

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2016

Tsutsui-Kimura I, Ohmura Y, Izumi T, Matsushima T, Amita H, Yamaguchi T, Yoshida T, Yoshioka M.

Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex.
Behavioural Brain Research, 2016 Jan 1;296:361-72. Epub 2015 Sep 2.

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2015

Ohmura Y, Yoshida T, Konno K, Minami M, Watanabe M, Yoshioka M.

Serotonin 5-HT7 receptor in the ventral hippocampus modulates the retrieval of fear memory and stress-induced defecation.
Int J Neuropsychopharmacol. 2015 Dec 8.

Ogura Y, Izumi T, Yoshioka M, Matsushima T.

Dissociation of the neural substrates of foraging effort and its social facilitation in the domestic chick.
Behav Brain Res. 2015 Nov 1;294:162-76. Epub 2015 Jul 30.

Chiba H, Mitsui T, Kitta T, Ohmura Y, Moriya K, Kanno Y, Yoshioka M,Shinohara N.

The role of serotonergic mechanism in the rat prefrontal cortex for controlling the micturition reflex: an in vivo microdialysis study.
Neurourol Urodyn. 2015 Jul 30

Lyttle K, Ohmura Y, Konno K, Yoshida T, Izumi T, Watanabe M, Yoshioka M.

Repeated fluvoxamine treatment recovers juvenile stress-induced morphological changes and depressive-like behavior in rats.
Brain Res. 2015 Aug;1616:88-100. Epub 2015 May 8.

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2014

Tsutsui-Kimura I, Yoshida T, Ohmura Y, Izumi T, Yoshioka M.

Milnacipran remediates impulsive deficits in rats with lesions of the ventromedial prefrontal cortex.
Int J Neuropsychopharmacol., 2014;18(5). pii: pyu083.

Inoue S, Shikanai H, Matsumoto M, Hiraide S, Saito Y, Yanagawa Y, Yoshioka M, Shimamura K, Togashi H.

Metaplastic regulation of the median raphe nucleus via serotonin 5-HT1A receptor on hippocampal synaptic plasticity is associated with gender-specific emotional expression in rats.
J Pharmacol Sci. 2014;124(3):394-407.

Ohmura Y, Tanaka F K, Tsunematsu T, Yamanaka A, Yoshioka M.

Optogenetic activation of serotonergic neurons enhances anxiety-like behavior in mice.
Int J Neuropsychopharmacol. 2014 Nov;17(11):1777-83.

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2013

Ide S, Hara T, Ohno A, Tamano R, Koseki K, Naka T, Maruyama C, Kaneda K, Yoshioka M, Minami M.

Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats
J Neurosci. 2013 Apr 3;33(14):5881-94

Ohmura Y, Kumamoto H, Tsutsui-Kimura I, Minami M, Izumi T, Yoshida T, Yoshioka M.

Tandospirone suppresses impulsive action by possible blockade of 5-HT1A receptor.
J Pharmacol Sci. 2013; 122(2):84-92. Epub 2013 May 24.

Naka T, Ide S, Nakako T, Hirata M, Majima Y, Deyama S, Takeda H, Yoshioka M, Minami M.

Activation of β-adrenoceptors in the bed nucleus of the stria terminalis induces food intake reduction and anxiety-like behaviors.
Neuropharmacology. 2013 Apr;67:326-30. Epub 2012 Dec 3.

Hiraide S, Ueno KI, Yamaguchi T, Matsumoto M, Yanagawa Y, Yoshioka M, Togashi H.

Behavioural effects of monoamine reuptake inhibitors on symptomatic domains in an animal model of attention-deficit/hyperactivity disorder.
Pharmacol Biochem Behav. 2013 Feb 1;105C:89-97. 

Tsutsui-Kimura I, Ohmura Y, Izumi T, Kumamoto H, Yamaguchi T, Yoshida T, Yoshioka M.

Milnacipran enhances the control of impulsive action by activating D(1)-like receptors in the infralimbic cortex.
Psychopharmacology (Berl). 2013 Jan;225(2):495-504. Epub 2012 Aug 15.

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2012

Izumi T, Ohmura Y, Futami Y, Matsuzaki H, Kubo Y, Yoshida T, Yoshioka M.

Effects of serotonergic terminal lesion in the amygdala on conditioned fear and innate fear in rats.
Eur J Pharmacol. 2012 Dec 5;696(1-3):89-95. Epub 2012 Oct 1.

Yoshioka M, Yamaguchi T, Ohta H, Gyotoku J, Miyamoto M, Ochiai T.

Effects of Parabolic Flight on Serotonin-Related Gene Expression in the Mouse Brain.
Gravitational and Space Biology. 2012 Oct;26 (2):22-29

Shikanai H, Yoshida T, Konno K, Yamasaki M, Izumi T, Ohmura Y, Watanabe M, Yoshioka M.

Distinct neurochemical and functional properties of GAD67-containing 5-HT neurons in the rat dorsal raphe nucleus.
J Neurosci. 2012 Oct 10;32(41):14415-26.

Yamaguchi T, Tsujimatsu A, Kumamoto H, Izumi T, Ohmura Y, Yoshida T, Yoshioka M.

Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT(1A) receptors on anxiety-related behaviors in rats experienced aversive stress.
J Ethnopharmacol. 2012 Sep 28;143(2):533-9. Epub 2012 Jul 20.

Matsunami S, Ogura Y, Amita H, Izumi T, Yoshioka M, Matsushima T.

Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks.
Behav Brain Res. 2012 Aug 1;233(2):577-86.

Ohmura Y, Tsutsui-Kimura I, Yoshioka M.

Impulsive behavior and nicotinic acetylcholine receptors.
J Pharmacol Sci. 2012;118(4):413-22. Epub 2012 Mar 22.

Hiraide S, Saito Y, Matsumoto M, Yanagawa Y, Ishikawa S, Kubo Y, Inoue S, Yoshioka M, Togashi H.

Possible modulation of the amygdala on metaplasticity deficits in the hippocampal CA1 field in early postnatally stressed rats.
J Pharmacol Sci. 2012 May 17;119(1):64-72. Epub 2012 Apr 28.

Yamaguchi T, Hamadate N, Sugawara A, Togashi H, Yamamoto T, Yoshioka M.

Liposome-encapsulated hemoglobin ameliorates brain dysfunction after transient cerebral ischemia in rats.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2012 Apr;32(2):97-9.

Yamaguchi T, Togashi H, Matsumoto M, Izumi T, Yoshioka M.

Impairment of emotional behaviors induced by early postnatal stress.
Nihon Yakurigaku Zasshi. 2012 Apr;139(4):142-6.

Ohmura Y, Tsutsui-Kimura I, Kumamoto H, Minami M, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.

Lithium, but not valproic acid or carbamazepine, suppresses impulsive-like action in rats.
Psychopharmacology (Berl). 2012 Jan;219(2):421-32.

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2011

Hamadate N, Yamaguchi T, Sugawara A, Tsujimatsu A, Izumi T, Yoshida T, Ohmura Y, Yoshioka M.

Regulation of cerebral blood flow in the hippocampus by neuronal activation through the perforant path: Relationship between hippocampal blood flow and neuronal plasticity
Brain Res., 2011; 1415:1-7.

Ohmura Y, Jutkiewicz EM, Yoshioka M, Domino EF.

5-Hydroxytryptophan attenuates somatic signs of nicotine withdrawal.
J. Pharmacol Sci. 2011;117(2):121-4.

Deyama S, Ide S, Kondoh N, Yamaguchi T, Yoshioka M, Minami M.

Inhibition of noradrenaline release by clonidine in the ventral bed nucleus of the stria terminalis attenuates pain-induced aversion in rats.
Neuropharmacology. 2011 Jul-Aug;61(1-2):156-60.

Matsuzaki H, Izumi T, Horinouchi T, Boku S, Inoue T, Yamaguchi T, Yoshida T, Matsumoto M, Togashi H, Miwa S, Koyama T, Yoshioka M.

Juvenile stress attenuates the dorsal hippocampal postsynaptic 5-HT(1A) receptor function in adult rats.
Psychopharmacology (Berl). 2011 Mar;214(1):1329-337

Izumi T, Boku S, Shinmin W, Inoue T, Konno K, Yamaguchi T, Yoshida T, Matsumoto M, Watanabe M, Koyama T, Yoshioka M.

Retrieval of conditioned fear activates the basolateral and intercalated nucleus of amygdala.
J Neurosci Res. 2011 May;89(5):773-90

Kimura S, Togashi H, Matsumoto M, Shiozawa T, Ishida J, Kano S, Ohashi A, Ishikawa S, Yamaguchi T, Yoshioka M, Shimamura K.

Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies.
Nihon Shinkei Seishin Yakurigaku Zasshi. 2011 Feb;31(1):9-15.

Yoshida T, Uchigashima M, Yamasaki M, Katona I, Yamazaki M, Sakimura K, Kano M, Yoshioka M, Watanabe M.

Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus.
Proc Natl Acad Sci U S A. 2011 Feb 15;108 (7) 3059-3064

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2010

Hamadate N, Yamaguchi T, Sugawara A, Togashi H, Izumi T, Yoshida T, Ohmura Y, Yoshioka M.

Liposome-encapsulated hemoglobin ameliorates impairment of fear memory and hippocampal dysfunction after cerebral ischemia in rats.
J. Pharmacol Sci. 2010 Dec 13;114(4):409-19.

Shikanai H, Izumi T, Matsumoto M, Togashi H, Yamaguchi H, Yoshida T, Yoshioka M.

Diazepam-induced increases of synaptic efficacy in the hippocampal-mPFC pathway are associated with its anxiolytic-like effect of rats.
J. Pharmacol Sci. 2010;114(3):341-6.

Yoshioka M, Yamaguchi T, Gyotoku J, Ochiai T, Ohta H.

Effect of parabolic flight on plasma arginine vasopressin as a sensitive marker for psychophysiological stress in humans.
Biol. Sci. Space. 2010 Oct;24(2):95-100.

Kakehata J, Yamaguchi T, Togashi H, Sakuma I, Otani H, Morimoto Y, Yoshioka M.

Therapeutic potentials of an artificial oxygen-carrier, liposome-encapsulated hemoglobin, for ischemia/reperfusion-induced cerebraldysfunction in rats.
J Pharmacol Sci. 2010 Oct;114(2):189-97.

Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.

Endogenous acetylcholine modulates impulsive action via alpha4beta2 nicotinic acetylcholine receptors in rats.
Eur J Pharmacol. 2010 Sep 1;641(2-3):148-53.

Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.

Nicotine provokes impulsive-like action by stimulating alpha4beta2 nicotinic acetylcholine receptors in the infralimbic, but not in the prelimbic cortex.
Psychopharmacology (Berl). 2010 May;209(4):351-9.

Tsutsui-Kimura I, Ohmura Y, Izumi T, Yamaguchi T, Yoshida T, Yoshioka M.

The serotonergic projection from the median raphe nucleus to the ventral hippocampus is involved in the retrieval of fear memory through the corticotropin-releasing factor type 2 receptor.
Neuropsychopharmacology. 2010 May;35(6):1271-8.

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2009以前